Musbau Lasisi
May & Baker Nigeria PLC, Nigeria
Title: Comparative in vitro dissolution study of multi-sourced (generic) Ketoprofen, extended-release capsules
Biography
Biography: Musbau Lasisi
Abstract
Dissolution testing is a very important in vitro test used as a mean of in vivo predictability and product performance. Dissolution testing has become one of the most used tests in many pharmacopoeias in the characterization and quality control of drugs in solid oral dosage forms and one of the foundations of solid dosage form design. Many proprietary and generic formulations commercially marketed in Nigeria are mostly from Asian countries. Nigerians buy these products because of their relative cheap prices but with doubtful minds with regards to efficacy, quality and safety. Health professionals usually entertain drug product selection and substitution during prescription and dispensing with caution. In this paper, the in vitro dissolution on three multi-sourced (generic) ketoprofen (200mg) capsules was carried out employing the UV absorption as explained in the US Pharmacopoeia. USP Ketoprofen RS was used as the primary standard. From the results; the percentage of the labelled amount of ketoprofen dissolved after 1 hour was found to be between 15% and 21%, 65% and 73% after 4 hours and 94% to 98% was the range obtained for the percentage of the label claim of ketoprofen dissolved after 8 hours. In conclusion, the three generic formulations of ketoprofen capsules were predictably in vivo available since the percentages of the labelled amount of ketoprofen released at the times specified conform to the USP requirements. Interchangeability of drugs in prescription and dispensing may be recommended in this situation.